New Ray of Hope for diabetics!

Type 2 diabetes comprises 90% of people with diabetes around the world, and is largely the result of excess body weight and physical inactivity.this fatal disease becoming a major epidemic for the world community which is already the burden of epidemics of aids , hypertension related disorders etc.

But a new discovery in Japan might be boon for type 2 Diabetics where a  hormone produced  and secreted by liver previously known for insulin resistance is the new focus. The discovery may be a new target for the treatment of insulin resistance and type 2 diabetes."The current study sheds light on a previously underexplored function of the liver; the liver participates in the pathogenesis of insulin resistance through hormone secretion," said Hirofumi Misu of Kanazawa University in Japan.

The researchers had discovered earlier that genes encoding secretory proteins are abundantly expressed in the livers of people with Type 2 diabetes. Now, the researchers reported the results of comprehensive gene expression analyses, revealing that the liver expresses higher levels of the gene encoding selenoprotein P (SeP) in people with type 2 diabetes who are more insulin resistant.

Further studies in mice added support to the notion that the connection between SeP and insulin resistance is causal. When the researchers gave normal mice SeP, they became insulin resistant and their blood sugar levels rose. 

A treatment that blocked the activity of SeP in the livers of diabetic and obese mice improved their sensitivity to insulin and lowered blood sugar levels.